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No certain dose adjustment proposed when tofacitinib coadministered with strong CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with equally moderate CYP3A4 and potent CYP2C19 inhibitors .Minimal (one)modafinil will improve the stage or result of lansoprazole by affecting hepatic enzyme CYP2C19 metabolism. Minor/Significance Mysteri